Luke, Cleo, and Resus battle millions of spiders as they attempt to retrieve the heart of an ancient mummy, which is the third relic Luke needs to escape Scream Street and take his terrified parents home.

Reluctant werewolf, Luke Watson, is Scream Street's latest arrival. With his new friends Resus Negative (wannabe vampire) and Cleo Farr (tomboy mummy), Luke thinks Scream Street might just be somewhere he can call home. However, there's one small problem. His parents are terrified by their new neighbors. Can Luke find the doorway back to the real world before they're scared to death?

When Luke Watson turns into a werewolf for the third time, he and his parents are moved to Scream Street, where they and other "unusual lifeforms" are trapped unless Luke and his friends can find six powerful relics hidden by the founding fathers before sinister landlord, Sir Otto, does.

"Opening a doorway out of Scream Street seems to have brought with it a whole new set of problems--and now Luke, Resus, and Cleo are beginning to realize what they have unleashed. Scream Street faces a greater threat than ever before: normals!"--